Composition: Each uncoated tablet contains : Diloxanide Furoate I.P................. 500 mg. Description: AMICLINE Tablets contain Diloxanide Furoate which is a amoebicide with good efficacy against the trophozoite and cystic forms of E. histolytica present in the intestinal lumen. Diloxanide Furoate is a dichloroacetamide derivative. After oral administration, high concentrations are reached in the intestinal lumen. Hence, it is very effective against the amoebic cysts and trophozoites in the lumen. It is well-tolerated and can be used in pregnancy. Its anti-amoebic efficacy is comparable to that of nitroimidazoles. Hence, it can be used in patients with intestinal amoebiasis, where nitroimidazoles are ineffective or are contraindicated. Indications: Asymptomatic cyst passers. In combination with tissue amoebicides for complete cure of amoebiasis. Anti-amoebic therapy, where: Patients are allergic to nitroimidazoles. Patients cannot tolerate the bad taste of nitroimidazoles. Patients get moderate to severe GI disturbances with nitroimidazoles. Patients are predisposed to CNS diseases, seizures or blood dyscrasias. Patient with recurrent amoebic colitis, where it is not safe to use nitroimidazoles repeatedly. Patient who are pregnant or lactating (After accessing risk-benefit ratio). Intestinal amoebiasis. In invasive (extra-intestinal) amoebiasis in conjugation with tissue amoebicide. Dosage: Adults - 1 tablet 3 times a day for 10 days, after meals. Children - 20 mg/kg body wt/day in divided doses for 10 days, after meals. Side Effects: Diloxanide Furoate is well-tolerated and the side effects observed with it are mild. These mainly consist of flatulence, anorexia, nausea, vomiting and pruritus. Precautions: No special precautions are required. Presentation: AMICLINE Tablets are available in a blister strip of 10 tablets. 10 such strips in a carton.