Amifostine (Amiget 500 mg Injection), Pack of 1 Vial

Amifostine is a prodrug that is dephosphorylated to an active ‘free' thiol metabolite that can reduce the toxic effects of cisplatin. Pretreatment with amifostine reduces cumulative renal toxicity from cisplatin. Hypotension during amifostine infusion should be minimized by adequately hydrating the patient prior to the infusion. Amifostine infusion should be interrupted if the systolic pressure decreases by more than 20-25% of the baseline reading. Nausea, vomiting and other gastrointestinal effects may be common in patients being treated with amifostine.