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Cyclophosphamide RC-B / RC-C / RC-D Monoethyl ester / Ethyl ester 3-Aminopropyl phosphate Piperazinyl propyl phosphate CAS: 158401-52-6 / 158401-51-5 / 2387771-96-0 / 2387771-94-8 Chloroethyl / Ethoxyethyl / Nitroso Related compound / Process impurity / Degradation product Nitrosamine impurity / Regulatory concern
CYCLOPHOSPHAMIDE AND IT’S RELATED COMPOUNDS
1. Cyclophosphamide RC-D Mono Ethyl Ester
A monoethyl ester derivative of Cyclophosphamide.
Likely used as a reference compound (RC) in impurity profiling or stability studies.
2. Cyclophosphamide RC-B Ethyl Ester
An ethyl ester variant categorized under RC-B.
Possibly formed as a degradation product or synthesis intermediate.
3. Cyclophosphamide RC-C Monethyl Ester: 3-Aminopropyl Ethyl Hydrogen Phosphate
Contains a 3-aminopropyl group with an ethyl hydrogen phosphate moiety.
Categorized under RC-C, indicating a related compound or process impurity.
4. Cyclophosphamide RC-C: 3-Aminopropyl Diethyl Phosphate
Similar to the above but with diethyl phosphate instead of ethyl hydrogen phosphate.
Suggests slight variation in esterification.
5. Cyclophosphamide Related Compound B
CAS: 158401-52-6
Registered compound, indicating known structure and properties.
Used for impurity profiling or analytical standards.
6. Cyclophosphamide Related Compound C
No specific structure or CAS provided.
Likely another known impurity or degradation product, tracked in pharmaceutical formulations.
7. Cyclophosphamide Related Compound D
CAS: 158401-51-5
Includes a chloroethyl side chain based on the partial structure visible.
Another known impurity, likely resulting from cyclophosphamide's decomposition or synthesis route.
8. Cyclophosphamide Related Compound F
Name: 2-((2-chloroethyl)(2-ethoxyethyl)amino)-1,3,2-oxazaphosphinane 2-oxide
CAS: 2387771-96-0
OR referred to as Compound F.
Structurally related to cyclophosphamide with substitutions on the nitrogen side chains.
9. Ethyl (3-(piperazin-1-yl)propyl) Hydrogen Phosphate
CAS: 2387771-94-8
Likely a derivative or impurity with a piperazine ring.
May arise in synthetic or degradation processes.
10. N-Nitroso Cyclophosphamide (Hydrate)
A nitrosated form of Cyclophosphamide.
Known for potential carcinogenicity and is a toxic impurity.
Requires careful monitoring in drug manufacturing.
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