Fosaprepitant Dimeglumine Injection

Fosaprepitant Dimeglumine Injection is an antiemetic medication used to prevent chemotherapy-induced nausea and vomiting (CINV). It is a prodrug of aprepitant and belongs to the class of neurokinin-1 (NK1) receptor antagonists.

• Active Ingredient: Fosaprepitant dimeglumine

• Drug Class: NK1 receptor antagonist

• Dosage Form: Lyophilized powder for injection

• Route of Administration: Intravenous infusion

• Prevention of acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy

• Used in combination with a 5-HT3 receptor antagonist and a corticosteroid

• Suitable for adult and selected pediatric patients as prescribed

Fosaprepitant is rapidly converted in the body to aprepitant, which blocks substance P from binding to NK1 receptors in the brain. This helps prevent the vomiting reflex triggered by chemotherapy.

• Provides effective control of both acute and delayed CINV

• Single-dose IV administration improves patient convenience

• Enhances overall tolerance of chemotherapy regimens

• Administered by IV infusion prior to chemotherapy

• Store below 25°C

• Reconstituted solution should be used as per clinical guidelines

• Common side effects include fatigue, headache, hiccups, and infusion-site reactions

• Potential drug interactions with certain chemotherapy agents and steroids

• Use only under medical supervision