Ketoconazole Powder

Here's a clear, professional "All About Ketoconazole API" write-up you can use for website, brochure, or marketing:

All About Ketoconazole API (IP/BP/USP)

CAS No.: 65277-42-1

Introduction

Ketoconazole is a widely used antifungal Active Pharmaceutical Ingredient (API) belonging to the imidazole class. It is highly effective in treating a broad spectrum of fungal and yeast infections affecting the skin, hair, nails, and internal organs.

About Ketoconazole

Ketoconazole works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption weakens the fungal cell structure, ultimately leading to cell death.

Chemical Information

• IUPAC Name:
  1-[4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

• Molecular Formula: C₂₆H₂₈Cl₂N₄O₄

• Molecular Weight: 531.43

• CAS Number: 65277-42-1

Physical & Quality Specifications

• Appearance: White crystalline powder

• Melting Point: 146–152°C

• Purity: IP / BP / USP

• Solubility: Slightly soluble in water, soluble in organic solvents

Pharmacopoeial Standards

Ketoconazole API complies with:

• IP (Indian Pharmacopoeia)

• BP (British Pharmacopoeia)

• USP (United States Pharmacopeia)

Applications

Ketoconazole is used in the formulation of:

• Antifungal tablets

• Creams and ointments

• Shampoos (anti-dandruff)

• Lotions and topical solutions

Therapeutic Uses

It is effective against:

• Dermatophytosis (ringworm infections)

• Candidiasis

• Seborrheic dermatitis

• Dandruff

• Systemic fungal infections

Mechanism of Action

Ketoconazole inhibits the enzyme responsible for converting lanosterol to ergosterol in fungal cells, leading to defective cell membrane formation and fungal cell death.

Manufacturing Intermediates

Key intermediates used in Ketoconazole production include:

• 1-Acetyl-4-(4-Hydroxyphenyl) Piperazine (AHPP)

• N,N-Bis (2-Chloroethyl) Amine HCl (BIS Salt)

• Cis Tosylate

Packaging & Supply

• Packaging: 25 kg HDPE bags/drums

• Minimum Order Quantity: 25 kg

• Supply Capacity: Up to 7000 kg

• Delivery Time: Within 1 week

Quality & Certifications

Manufactured under strict quality control with certifications such as:

• ISO 9001:2015

• ISO 14001:2015

• ISO 45001:2018

Storage & Handling

• Store in a cool, dry place

• Protect from light and moisture

• Keep container tightly closed

Safety Information

• Handle using proper PPE

• Avoid inhalation and direct contact

• Refer to MSDS for detailed safety guidelines

Why Choose Darshan Pharmachem?

• Trusted Ketoconazole API manufacturer in India

• Consistent quality meeting global standards

• Strong production capacity

• Reliable and timely delivery

• Competitive pricing