LIFITEGRAST METABOLITES Bioinsecticide Powder (Azadirachtin - Neem)

Lifitegrast is an LFA-1 antagonist widely used in ophthalmic formulations for the treatment of dry eye disease. It acts by blocking the LFA-1/ICAM-1 interaction, reducing ocular surface inflammation. After topical administration, systemic exposure remains very low, and the compound undergoes limited metabolism. Its main metabolic pathways involve slow hydrolysis and mild oxidative cleavage, forming minor metabolites such as desmethyl-lifitegrast, hydroxy-lifitegrast, and aromatic cleavage fragments.

· R-Lifitegrast — CAS 2271299-08-0

• Lifitegrast Impurity 5 — CAS 2129597-34-6
• Lifitegrast Impurity 14 — CAS 2129597-34-6
• Lifitegrast tert-Butyl Ester Impurity — CAS 2414639-05-5
• Lifitegrast Impurity 15 — CAS 2414639-05-5
• Lifitegrast Ethyl Ester Impurity — CAS 2295862-24-5
• Lifitegrast (API Reference Standard) — CAS 1025967-78-5
• Lifitegrast Impurity 1
• Lifitegrast Impurity 3
• Hydroxy Lifitegrast
• Hydrolytic Degradation Impurities
• Oxidative Degradation Impurities
• Photolytic Degradation Impurities
• Nitrosamine

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