Helicobacter pylori is a bacterium found in the gastrointestinal tract of up to 60 percent or two-thirds of the world’s population. Most individuals infected with it will not develop symptoms or be affected by it. However, H. pylori can cause several gastrointestinal disorders, including ulcers, stomach cancer and chronic gastritis (inflammation of the stomach). The bacterium releases enzymes that allow it to invade the lining of the stomach and the first part of the small intestine, called the duodenum. These areas are then more vulnerable to damage from the stomach’s digestive acid and this, in turn, may cause chronic inflammation in the stomach (gastritis) or duodenum (duodenitis), and sometimes ulcer formation. The actual source of H. pylori infection is unknown but is thought to include swimming in, or drinking, fecal-contaminated water, or eating uncooked vegetables. Proper precautions include washing the hands (15-30 seconds with antibacterial soap), drinking clean water from a reliable source and eating only well-cooked foods.Symptoms of H. pylori infection include the following:
Upper abdominal pain (often described as a burning or gnawing pain)
Nausea and/or vomiting Decreased appetiteDark stools (blood passed from the stomach through the intestines produces dark stools)H. pylori can be diagnosed in a number of ways, including blood tests that look for antibodies made by the body in response to the infection. Other tests include stool studies that detect proteins produced by the bacterium, and a breath test. The breath test involves swallowing a substance that is degraded by the bacteria and can then be detected by sampling a patient’s breath.
Another more invasive method is endoscopy, where a specialized, flexible tube is placed through the mouth, past the esophagus and into the stomach. The tube contains a camera and light that allow the physician to view the esophagus, stomach and duodenum and take biopsies for H. pylori testing.
H. pylori is treated with a combination of at least two antibiotics and a proton-pump inhibitor for 7 to 14 days. The combination of medications has about a 90 percent cure rate when the patient takes all the medication as prescribed.
H. pylori produce large amounts of the enzyme urease. Although the primary function of urease is to allow H. pylori to utilize urea as a nitrogen source, the breakdown of urea also produces high local concentrations of ammonia. When a tissue specimen from a patient is assayed by the HelicoRapt test, the elevated pH level produced by the presence and activity of urease is indicated by a color change in the test paper.
|Catalog No||Description||Pack size|
|RAHPYZ001P0050|| HelicoRapt (rapid detection kit for H. pylori)||50|
|RAHPYZ001P0100||HelicoRapt (rapid detection kit for H. pylori)||100|