Wang Resin

Wang resin (4-Benzyloxybenzyl Alcohol Resin) is the standard peptide synthesis resin used with Fmoc chemistry. Wang resin is acid labile and finished peptides can be easily cleaved by treatment with 50% (v/v) TFA/DCM. . The ester linkage may be achieved, which has good stability to a variety of reaction conditions, but can be readily removed with the moderate acid treatment, generally with trifluoroacetic acid. These relatively mild cleavage conditions have made this resin popular in solid phase organic synthesis also.As a standard support it can be used for the solid phase immobilization of acids and phenols. For the immobilization of amines, Wang resin also can be readily converted into solid phase equivalents of standard urethane-based protecting groups by reaction with phosgene or activated carbonates, such as carbonyl diimidazole or bis(p-nitropnenyl)-carbonate.